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Cohort study of Helicobacter pylori infection and the risk of incident osteoporosis in women
Author(s) -
Kim Tae Jun,
Lee Hyuk,
Min Yang Won,
Min ByungHoon,
Lee Jun Haeng,
Rhee PoongLyul,
Kim Jae J
Publication year - 2021
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.15181
Subject(s) - medicine , osteoporosis , body mass index , hazard ratio , cohort , cohort study , helicobacter pylori , risk factor , confidence interval
Background and Aim Previous studies suggested an association between Helicobacter pylori infection and osteoporosis; however, large‐scale longitudinal studies are lacking to elucidate this association. Methods A cohort study of 10 482 women without osteoporosis at baseline who participated in a repeated health‐screening examination including an H. pylori ‐specific immunoglobulin G antibody test was conducted to evaluate the association between H. pylori and osteoporosis development. Osteoporosis was diagnosed using dual‐energy X‐ray absorptiometry. Results During the 77 515.3 person‐years of follow‐up, women with H. pylori infection had a higher rate of incident osteoporosis than those who were uninfected. In a multivariable model adjusted for age, body mass index (BMI), menopausal status, smoking status, regular exercise, comorbidities (including hypertension, diabetes mellitus, dyslipidemia, stroke, or ischemic heart disease), and concomitant medications, the hazard ratio (HR) for incident osteoporosis in women with H. pylori infection compared with that in women without infection was 1.23 (95% confidence interval [CI], 1.03–1.45). The association between H. pylori and osteopenia development was also evident. In the multivariable analysis, menopause (HR, 1.68; 95% CI, 1.31–2.16) and increasing age (HR, 1.07; 95% CI, 1.06–1.08) were identified as significant risk factors for osteoporosis, whereas higher BMI (HR, 0.84; 95% CI, 0.81–0.87) was a protective factor for the risk of osteoporosis. Conclusions In this cohort study, H. pylori infection was associated with an increased risk of osteoporosis, independent of risk factors and confounding factors.