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Elevated fecal calprotectin and lactoferrin associated with small intestinal lesions in patients with Behçet disease
Author(s) -
Hayashida Mari,
Miyoshi Jun,
Mitsui Tatsuya,
Miura Miki,
Saito Daisuke,
Sakuraba Akihito,
Kawashima Soko,
Ikegaya Noriko,
Fukuoka Kazuhito,
Karube Miho,
Komagata Yoshinori,
Kaname Shinya,
Okada Annabelle A,
Fujimori Shunji,
Matsuura Minoru,
Hisamatsu Tadakazu
Publication year - 2020
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14995
Subject(s) - medicine , gastroenterology , calprotectin , behcet's disease , capsule endoscopy , perforation , feces , ulcerative colitis , body mass index , lactoferrin , disease , inflammatory bowel disease , paleontology , genetics , biology , punching , metallurgy , materials science
Background and Aims Small intestinal lesions in patients with Behçet disease (BD) have a risk of perforation and hemorrhage requiring surgery. However, no screening strategy for such lesions has been established. We investigated small intestinal lesions in BD patients with video capsule endoscopy (VCE) and analyzed clinical characteristics to identify noninvasive biomarkers of such lesions. Methods This study included 33 BD patients who underwent VCE (PillCam® SB3) at our institution from June 2016 to January 2019. Clinical characteristics, including age, sex, disease duration, body mass index, gastrointestinal symptoms, eye involvement, and blood examinations, were obtained from the medical records of 27 of the 33 patients. Fecal immunochemical tests for hemoglobin, fecal calprotectin (FC), and fecal lactoferrin (FL) were measured. VCE findings of 145 healthy Japanese individuals from a previous report were used as controls. Results Two intestinal BD patients were included in the 27 patients. We observed that BD patients exhibit more small intestinal lesions compared with healthy individuals, including erosions, ulcers, and total lesions (erosions or ulcers). FC and FL levels were significantly higher in patients with versus without small intestinal lesions ( P = 0.034 and P = 0.046, respectively). Receiver operating characteristic analyses demonstrated that FC (cutoff value = 119 μg/g) and FL (cutoff value = 17 μg/g) were biomarkers for small intestinal lesions in patients with BD. Conclusion The present study using VCE showed that patients with BD had more small intestinal lesions than healthy individuals. FC and FL could be useful for screening BD patients who may have small intestinal lesions.