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Long‐term results of variceal bleeding management in 302 patients with chronic extrahepatic portal vein obstruction
Author(s) -
Chen Hui,
He Chuangye,
Lv Yong,
Fan Jiahao,
Tang Shihao,
Niu Jing,
Yuan Jie,
Luo Bohan,
Guo Wengang,
Yin Zhanxin,
Han Guohong
Publication year - 2020
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14902
Subject(s) - medicine , transjugular intrahepatic portosystemic shunt , varices , gastroenterology , portal hypertension , portal vein thrombosis , portal venous pressure , sclerotherapy , portosystemic shunt , surgery , portal vein , cirrhosis
Background and Aim Treatment modalities of variceal bleeding or rebleeding for extrahepatic portal vein obstruction (EHPVO) are limited, and their long‐term results and prognostic factors are unclear. This study aimed at assessing the long‐term results of EHPVO treated with current recommendations and investigating the influencing factors. Methods Between 2009 and 2016, 302 consecutive patients with EHPVO were included. Watch‐and‐wait policy was applied for those with no ( n = 59) or small varices ( n = 55), nonselective beta‐adrenergic blocker and nonselective beta‐adrenergic blocker plus endotherapy were for primary ( n = 115) and secondary prophylaxis ( n = 87), transjugular intrahepatic portosystemic shunt (TIPS) or combination therapy was for those with recurrent bleeding ( n = 92). Results The median follow up was 58.8 months. The 1‐, 3‐, and 5‐year cumulative rates were 3.6%, 19.2%, 32.3% for small varices development and 4.5%, 30.9%, 53.4% for large varices development. The 1‐, 3‐, and 5‐year cumulative rates were 11.1%, 20.9%, and 34.9% for first variceal bleeding and 16.0%, 26.9%, and 33.6% for variceal rebleeding. For those with recurrent variceal bleeding, only TIPS ( n = 37, technical success rate: 90.2%) was associated with a reduced risk of variceal rebleeding (1‐, 3‐, and 5‐year: 5.6%, 11.7%, and 21.9%). The 1‐, 3‐, and 5‐year survival rates were 96.9%, 95.8%, and 91.9%. Prothrombotic factors and anticoagulation did not influence the risk of variceal bleeding, rebleeding, and survival. Conclusions By applying the same variceal management as recommended for patients with liver cirrhosis, patients with non‐cirrhotic EHPVO showed a similar development of varices and variceal bleeding. This is also true for the beneficial effect of TIPS to prevent rebleeding.