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Infliximab for very early‐onset inflammatory bowel disease: A tertiary center experience in Japan
Author(s) -
Takeuchi Ichiro,
Kaburaki Yoichiro,
Arai Katsuhiro,
Shimizu Hirotaka,
Hirano Yuri,
Nagata Satoru,
Shimizu Toshiaki
Publication year - 2020
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14836
Subject(s) - infliximab , medicine , ulcerative colitis , inflammatory bowel disease , refractory (planetary science) , tertiary care , retrospective cohort study , cohort , crohn's disease , disease , surgery , gastroenterology , physics , astrobiology
Background and Aim Very early‐onset inflammatory bowel disease (VEO‐IBD), defined as IBD diagnosed before 6 years of age, tends to be refractory to conventional treatment for IBD. However, there have been a few reports about the usage of infliximab for VEO‐IBD. This study aimed to evaluate the efficacy and safety of infliximab for VEO‐IBD. Methods Medical records of a cohort of children with VEO‐IBD who had received infliximab in a Japanese tertiary children's hospital were retrospectively reviewed for their disease characteristics and clinical course. Subjects were categorized into three groups for the descriptive comparison: ulcerative colitis type (UCT), non‐UCT with perianal disease (NUC‐PD), and non‐UCT without perianal disease (NUC‐NPD). Results Seventeen VEO‐IBD patients (five UCT, five NUC‐PD, and seven NUC‐NPD) had received infliximab as their first biologic. In the UCT group, infliximab was continued over 54 weeks in two patients, and three eventually required surgery. In contrast, all patients in the NUC‐PD and NUC‐NPD groups followed up over 54 weeks remained on infliximab, and two of three patients and three of five patients were in remission at week 54, respectively. Infusion reactions occurred in all five UCT, three of five NUC‐PD, and two of seven NUC‐NPD patients; however, except for two patients with severe reactions, infliximab was continued with premedication and slow infusions. Conclusions Infliximab appeared useful for children with VEO‐IBD. Children with NUC‐PD and NUC‐NPD responded better with less infusion reaction compared with that with UCT.