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Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population
Author(s) -
Lv Tingting,
Li Min,
Zeng Na,
Zhang Jingqi,
Li Shuxiang,
Chen Sha,
Zhang Chunpan,
Shan Shan,
Duan Weijia,
Wang Qianyi,
Wu Shanshan,
You Hong,
Ou Xiaojuan,
Ma Hong,
Zhang Dong,
Kong Yuanyuan,
Jia Jidong
Publication year - 2019
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14746
Subject(s) - medicine , incidence (geometry) , meta analysis , confidence interval , population , subgroup analysis , epidemiology , demography , cochrane library , autoimmune hepatitis , prevalence , hepatitis , environmental health , physics , sociology , optics
Background and Aim Reported incidence and prevalence rates of autoimmune hepatitis (AIH) have been sparse and heterogeneous. The aim of this meta‐analysis was to estimate the worldwide incidence and prevalence rates of AIH and reveal population difference. Methods Published articles on the epidemiology of AIH in PubMed, Embase, and Cochrane Library were systematically searched from inception to April 28, 2019. Two investigators independently reviewed these literatures and evaluated their quality. A random‐effects model was used to pool the overall incidence and prevalence rates. The impact of population difference, gender, age, study period, study quality, diagnostic criteria, and study design was further analyzed with subgroup analysis and meta‐regression. Results A total of 22 studies were included in the meta‐analysis. The pooled worldwide annual incidence and prevalence of AIH were 1.37 (95% confidence interval [CI]: 0.95–1.80) and 17.44 (95% CI: 12.01–22.87) per 100 000 persons, respectively. Subgroup analysis showed that the pooled annual incidence for Asian, European, and American population was 1.31 (95% CI: 0.42–2.20), 1.37 (95% CI: 1.10–1.64), and 1.00 (95% CI: 0.44–1.56) per 100 000 persons, respectively; the pooled prevalence for Asian, European, and American population was 12.99 (95% CI: 2.05–23.92), 19.44 (95% CI: 15.63–23.24), and 22.80 (95% CI: −13.48 to 59.07) per 100 000 persons, respectively. In addition, higher incidence and prevalence rates were observed in women than men, and a higher prevalence rate was observed in elderly than young people. Conclusions Autoimmune hepatitis is a rare disease, with a similar incidence worldwide and a higher prevalence in European and American than in Asian population.