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Association of TRAP1 with infliximab‐induced mucosal healing in Crohn's disease
Author(s) -
Park Sang Hyoung,
Hong Myunghee,
Lee HoSu,
Ye Byong Duk,
Hwang Sung Wook,
Jung Seulgi,
Baek Jiwon,
Moon Jung Won,
Kim Byoung Mok,
Oh Seak Hee,
Kim Kyung Mo,
Lee Inchul,
Im ChangNim,
Liu Jianjun,
McGovern Dermot P B,
Yang SukKyun,
Song Kyuyoung
Publication year - 2019
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14696
Subject(s) - medicine , infliximab , crohn's disease , ulcerative colitis , inflammatory bowel disease , single nucleotide polymorphism , gastroenterology , genome wide association study , snp , tumor necrosis factor alpha , odds ratio , maintenance therapy , disease , immunology , genotype , gene , chemotherapy , biochemistry , chemistry
Background and Aim Anti‐tumor necrosis factor (TNF) agents, such as infliximab (IFX), have been increasingly used to induce and maintain disease remission in patients with Crohn's disease (CD). Despite a considerable non‐response rate, little is known about the genetic predictors of response to anti‐TNF therapy in CD. Our aim in this study was to investigate the genetic factors associated with response to anti‐TNF therapy in patients with CD. Methods We performed a two‐stage genome‐wide association study (GWAS) to identify loci influencing the response to IFX among Korean patients with CD, comprising 42 good responders with mucosal healing and 70 non‐responders. The achievement of mucosal healing was assessed by endoscopy and imaging. The functional significance of TRAP1 (TNF receptor associated protein 1) was examined using dextran sodium sulfate‐induced colitis model in TRAP1 transgenic mice. Results The GWAS identified rs2158962, an intronic single nucleotide polymorphism (SNP) of TRAP1 , significantly associated with mucosal healing (odds ratio = 4.94; P combined = 1.35 × 10 −7 ). In the dextran sodium sulfate‐induced acute colitis, TRAP1 transgenic mice showed a better response to IFX than the wild‐type mice. Conclusions The TRAP1 gene is associated with mucosal healing in CD patients following IFX therapy. Identifying the genetic predictors of mucosal healing to anti‐TNF therapy can prevent patients from exposure to ineffective therapies.