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Predictor of slower gastric emptying in gastroesophageal reflux disease: Survey of an Asian‐Pacific cohort
Author(s) -
Wang KuanYuan,
Chen YuWen,
Wang TsuNai,
Hsu WenHung,
Wu IChen,
Yu FangJung,
Hu HuangMing,
Wu JengYih,
Kuo ChaoHung,
Lu ChienYu,
Wu DengChyang,
Su YuChung
Publication year - 2019
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14572
Subject(s) - gastric emptying , medicine , gastroenterology , reflux , cohort , helicobacter pylori , disease , depression (economics) , cohort study , stomach , economics , macroeconomics
Background and Aim Asian populations have relatively lower prevalence of gastroesophageal reflux disease and tend to exhibit symptoms of prolonged gastric retention. However, it remains unknown if slower gastric emptying influences its features in Asian countries. We prospectively assessed the potential implications of slower gastric emptying in an Asian‐Pacific cohort of gastroesophageal reflux disease by a hospital‐based survey. Methods One hundred fifty‐two patients of gastroesophageal reflux disease complete the scintigraphic measurement of solid phase of gastric emptying. Clinical symptoms and psychological stress are recorded by self‐report questionnaire. The status of Helicobacter pylori infection, blood level of pepsinogen I, and I/II ratio are assessed. Results Forty‐seven percent and 28% of the patients have slower gastric emptying rate, depending on the incremental defined cut‐off values of slower gastric emptying, respectively. Multiple logistic regression analysis indicates that older age and depression score are independently related to slower gastric emptying. Subgroup analysis discloses that patients with slower gastric emptying and higher depression score tend to present with non‐erosive esophagitis whereas higher body mass index level and male gender in patients with normal gastric emptying predict the presence of erosive reflux disease. Conclusions Our study cohort of Asian patients indicates distinctive clinical implications of slower gastric emptying in patients with gastroesophageal reflux disease.