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Incidence, inhospital mortality, and readmission among patients with alcoholic hepatitis in Korea: A nationwide study
Author(s) -
Lee Jin Yong,
Cho Yuri,
Hong Min Hee,
Kim Jayeun,
Lee Dong Hyeon,
Jung Yong Jin,
Kim Byeong Gwan,
Lee Kook Lae,
Kim Won
Publication year - 2019
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14513
Subject(s) - medicine , incidence (geometry) , mortality rate , logistic regression , alcoholic hepatitis , odds ratio , cirrhosis , alcoholic liver disease , emergency medicine , pediatrics , physics , optics
Background and Aim Alcoholic hepatitis (AH) ranks among the most costly diseases in South Korea. However, accurate hospitalization incidence rates, mortality rates, and contributing factors have not been investigated in South Korea. This study aimed to provide the nationwide incidence of hospitalization, inhospital mortality, and readmission rates for South Korean patients with AH. Methods Using the Korean Health Insurance Review and Assessment service database, a total of 39 800 inpatient cases from 2008 to 2012 were identified based on the International Classification of Diseases, 10th Revision diagnosis code for AH (K70.1). Standardized hospitalization incidence and mortality rates were calculated, and logistic regression analysis was performed to identify risk factors for inhospital mortality and readmission. Follow‐up data for those admitted in 2008 were collected to assess readmissions. Results The standardized incidence rate for AH hospitalization per 10 5 person/year decreased from 19 in 2008 to 14 in 2012 ( P = 0.001). The annual inhospital mortality rate ranged from 0.2% to 0.5%. Inhospital mortality was significantly higher in older patients (odds ratio [OR], 1.36) and those with cirrhosis (OR, 4.40). The readmission rate for patients admitted in 2008 was 34.0%. Male sex (OR, 1.21) and low economic status (OR, 2.35) were significantly associated with readmission, whereas older age (OR, 0.96), cirrhosis (OR, 0.77), and urban residency (OR, 0.68) were inversely associated with readmission. Conclusions This study captured a 5‐year epidemiologic period in South Korea of patients with AH to reflect the real burden of AH and to provide valuable information to policy‐makers assessing public health priorities.