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Comparison of a novel predictor of venous thromboembolic complications in inflammatory bowel disease with current predictors
Author(s) -
Ohta Yuki,
Arai Makoto,
Nakagawa Tomoo,
Akizue Naoki,
Ishikawa Kentaro,
Hamanaka Shinsaku,
Koseki Hirotaka,
Taida Takashi,
Okimoto Kenichiro,
Saito Keiko,
Yoshihama Sayuri,
Maruoka Daisuke,
Matsumura Tomoaki,
Katsuno Tatsuro,
Kato Naoya
Publication year - 2019
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14472
Subject(s) - medicine , hazard ratio , inflammatory bowel disease , d dimer , confidence interval , receiver operating characteristic , proportional hazards model , venous thromboembolism , area under the curve , complication , disease , thrombosis
Background and Aim Venous thromboembolism (VTE) is a common complication of inflammatory bowel disease (IBD). The aim of the present study was to identify predictors of VTE in hospitalized patients with IBD. Methods Patients with IBD who were hospitalized from February 2015 to March 2016 at the Chiba University Hospital were included. VTE was detected using enhanced computed tomography, and VTE onset within 2 months after admission was assessed. Predictors of VTE onset were investigated with clinical factors during hospitalization. Availability of the Caprini risk assessment model and Padua prediction score at the time of admission was also assessed. Results Seventy‐two patients with IBD were hospitalized, and central venous catheters were placed in 43 of the 72 patients. During the observation period, VTE occurred in six patients (8.3%); however, none died as a result of the condition. Cox proportional hazards regression analysis identified D‐dimer values on admission as a risk factor that was highly associated with VTE onset (hazard ratio = 1.590; 95% confidence interval, 1.132–2.233; P = 0.007) and significantly predicted the occurrence of VTE using the receiver operating characteristic curve ( P = 0.005, area under the curve = 0.893). However, Caprini risk assessment model and Padua prediction scores were not useful tools for predicting VTE onset in patients with IBD. Conclusion In hospitalized patients with IBD, D‐dimer values were highly associated with VTE onset. Therefore, measurement of D‐dimer values on admission is critical for the management of thromboembolic complications in patients with IBD.