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Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein in decompensated cirrhosis
Author(s) -
Uojima Haruki,
Hidaka Hisashi,
Tanaka Yoshiaki,
Inoue Tomoyoshi,
Onoue Mie,
Wada Naohisa,
Kubota Kousuke,
Nakazawa Takahide,
Shibuya Akitaka,
Fujikawa Tomoaki,
Nakayama Tsuyoshi,
Yamanoue Hiroki,
Sung Ji Hyun,
Kako Makoto,
Koizumi Wasaburo
Publication year - 2018
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14277
Subject(s) - medicine , cirrhosis , gastroenterology , receiver operating characteristic
Background and Aim An assay for Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein (WFA + ‐M2BP) has been reported as a useful non‐invasive marker for the evaluation of the staging of fibrosis in several chronic liver diseases. However, available data on the effect of WFA + ‐M2BP level in decompensated cirrhosis patients were limited. It is important that these investigations can validate the diagnostic utility of WFA + ‐M2BP in the full range of patients with liver cirrhosis. Methods A multicenter study was conducted at five locations in Japan. A total of 207 patients with liver cirrhosis were enrolled in the present study. To determine whether or not the WFA + ‐M2BP value was associated with a progression of fibrosis among cirrhosis, this study examined WFA + ‐M2BP levels between patients with cirrhosis in the decompensated and compensated groups. Results The numbers and proportions of compensated and decompensated patients were 113 (54.6%) and 94 (45.4%), respectively. The average WFA + ‐M2BP levels were 2.22 ± 1.61 in the compensated group and 6.91 ± 5.04 in the decompensated group. Significantly higher WFA + ‐M2BP levels were observed in the decompensated group than those in the compensated group ( P < 0.0001). The respective cut‐off index values for decompensated cirrhosis were estimated using receiver‐operating characteristic curves for WFA + ‐M2BP levels. Using a cut‐off index value of 3.37 for WFA + ‐M2BP, predicting decompensated cirrhosis had a sensitivity of 77.8% and a specificity of 86.7%. Conclusions WFA + ‐M2BP values were higher in patients with decompensated liver cirrhosis.