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Prediction of carotid intima–media thickness in obese patients with low prevalence of comorbidities by serum copper bioavailability
Author(s) -
Tarantino Giovanni,
Porcu Cristiana,
Arciello Mario,
Andreozzi Paola,
Balsano Clara
Publication year - 2018
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14104
Subject(s) - medicine , bioavailability , intima media thickness , copper , gastroenterology , cardiology , carotid arteries , pharmacology , metallurgy , materials science
Abstract Background and Aim Western societies, with growing prevalence, suffer from various metabolic diseases like obesity and hepatic steatosis, better defined as non‐alcoholic fatty liver disease, or cardiovascular (CV) diseases that are strictly linked to each other. The association of their occurrence with the altered homeostasis of metals is an intriguing issue. Copper in particular was identified as key player in various metabolic derangements. On these bases, we aimed at investigating the possible association of serum copper levels with an indicator of early CV risk as the intima–media thickness (IMT) of carotid artery and its predictive value in a selected population of obese patients. Methods We performed a cross‐sectional study recruiting 100 obese patients characterized by a low prevalence of comorbidities. Ultrasound investigation for hepatic steatosis and IMT evaluation were performed. Serum samples were collected and then analyzed through atomic absorption spectrometry to evaluate their copper content. Possible correlations between copper bioavailability and biochemical, clinical, and anthropometric characteristics of patients were sought. Results Age negatively predicted copper serum levels of patients ( P = 0.009). However, the most interesting finding is the negative prediction of IMT by the copper serum levels ( t = −2.23, P = 0.028, least absolute deviations regression). Factor analysis confirmed the aforementioned inverse correlation and highlighted the strong inverse correlation between smoking and copper serum levels. Conclusion Our data show that an altered copper bioavailability predicts early atherosclerosis as main CV risk in obese patients with hepatic steatosis detected by ultrasound, shedding some light in this pathological scenario.