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Performance of F‐18 FDG PET/CT for predicting malignant potential of gastrointestinal stromal tumors: A systematic review and meta‐analysis
Author(s) -
Kim SeongJang,
Lee SangWoo
Publication year - 2018
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.14015
Subject(s) - medicine , meta analysis , diagnostic odds ratio , positron emission tomography , gist , confidence interval , odds ratio , nuclear medicine , cochrane library , receiver operating characteristic , radiology , stromal cell
Background and Aim We aimed to explore the role of the diagnostic accuracy of F‐18 fluorodeoxyglucose positron emission tomography (F‐18 FDG PET) or positron emission tomography/computed tomography (PET/CT) for prediction of malignant potential of gastrointestinal stromal tumor (GIST) through a systematic review and meta‐analysis. Methods The MEDLINE, Embase, and Cochrane Library database, from the earliest available date of indexing through May 31, 2017, were searched for studies evaluating the diagnostic performance of F‐18 FDG PET or PET/CT for prediction of malignant potential of GIST. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR−), and constructed summary receiver operating characteristic curves. Results Across seven studies (188 patients), the pooled sensitivity for F‐18 FDG PET or PET/CT was 0.88 (95% confidence interval [CI]: 0.80–0.94) without heterogeneity ( χ 2 = 6.15, P = 0.72) and a pooled specificity of 0.88 (95% CI: 0.75–0.94) with heterogeneity ( χ 2 = 23.2, P = 0.01). LR syntheses gave an overall LR+ of 7.2 (95% CI: 3.3–15.3) and LR− of 0.13 (95% CI: 0.07–0.24). The pooled diagnostic odds ratio was 54 (95% CI: 16–181). Conclusion F‐18 FDG PET or PET/CT demonstrated good sensitivity and specificity for the prediction of malignant potential of GIST. At present, the literature regarding the use of F‐18 FDG PET or PET/CT for the prediction of malignant potential of GIST remains still limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of F‐18 FDG PET or PET/CT prediction of malignant potential of GIST.