Premium
CpG island methylator phenotype is an independent predictor of survival after curative resection for colorectal cancer: A prospective cohort study
Author(s) -
Kim Chang Hyun,
Huh Jung Wook,
Kim Hyeong Rok,
Kim Young Jin
Publication year - 2017
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13734
Subject(s) - medicine , colorectal cancer , perineural invasion , oncology , stage (stratigraphy) , cancer , dna methylation , gastroenterology , multivariate analysis , proportional hazards model , cohort , biology , gene , paleontology , biochemistry , gene expression
Background and Aims The CpG island methylator phenotype (CIMP) is found in approximately 30% of colorectal cancer (CRC) cases. However, the role of CIMP status in predicting oncologic outcomes in curatively resected CRC is still unclear. Study Between January 2006 and December 2006, we retrospectively reviewed 157 consecutive patients who underwent curative surgery for CRC. Prognostic significance of CIMP status was evaluated using reverse transcriptase‐polymerase chain reaction. Results CIMP‐high (H) and CIMP‐none/low (N/L) tumors were found in 50 cases (31.8%) and 107 cases (68.2%), respectively. CIMP‐H tumors were significantly associated with female sex, colonic location, poorly/mucinous histologic type, higher T category, perineural invasion, and MSI‐high status ( P = 0.001). During a median of 64.5 months, tumor recurrence developed in 47 (29.9%) patients. The 5‐year disease‐free survival for CIMP‐H and CIMP‐N/L was 61.4% and 76.3% ( P = 0.018). In addition, multivariate analysis showed that CIMP‐H was also a significant prognostic factor ( P = 0.042). When analysis was performed according to anatomical location, more marked survival differences were observed in patients with colon cancer ( P = 0.026) than in patients with rectal cancer ( P = 0.210). Similarly, the role of CIMP status as a prognostic indicator was more prominent in patients with stage I/II ( P = 0.006) than in patients with stage III/IV CRC ( P = 0.65). Conclusions DNA methylation status can be considered as a useful predictor of survival after CRC surgery, particularly for patients with stage I/II disease or colon cancer.