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Application of the combined FibroMeter vibration‐controlled transient elastography algorithm in Chinese patients with non‐alcoholic fatty liver disease
Author(s) -
Loong Thomson ChiWang,
Wei Jeremy Lok,
Leung Jonathan ChungFai,
Wong Grace LaiHung,
Shu Sally SheTing,
Chim Angel MeiLing,
Chan Anthony WingHung,
Choi Paul CheungLung,
Tse YeeKit,
Chan Henry LikYuen,
Wong Vincent WaiSun
Publication year - 2017
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13671
Subject(s) - transient elastography , medicine , fatty liver , transient (computer programming) , alcoholic liver disease , gastroenterology , algorithm , disease , pathology , biopsy , computer science , cirrhosis , liver biopsy , operating system
Background and Aim The FibroMeter vibration‐controlled transient elastography (FM VCTE) is a new formula combining the serum test FM and liver stiffness measurement (LSM) by VCTE. We tested the accuracy and utility of FM VCTE for fibrosis staging in patients with non‐alcoholic fatty liver disease (NAFLD). Methods Two hundred fifteen NAFLD patients with LSM, FM NAFLD, FM VCTE, and other serum tests (aspartate aminotransferase‐to‐platelet ratio index, fibrosis‐4 index, BARD score, NAFLD fibrosis score, and aspartate aminotransferase‐to‐alanine aminotransferase ratio) performed 1 day before liver biopsy were evaluated. Results Sixty‐nine (32.1%) and 43 (20.0%) patients had F2‐4 and F3‐4, respectively. LSM had higher diagnostic accuracy (area under receiver‐operating characteristics curves [AUROC] 0.851 for F2‐4, 0.940 for F3‐4; Obuchowski index 0.937 ± 0.007) than all evaluated serum tests, while FM NAFLD was the most accurate serum test (AUROC 0.775 and 0.774; Obuchowski index 0.891 ± 0.013). FM VCTE had similar accuracy to LSM (AUROC 0.855 and 0.901; Obuchowski index 0.927 ± 0.009). LSM had excellent negative predictive values of 92.4% and 99.2% to exclude F2‐4 and F3‐4, but the positive predictive values (PPV) were only 71.4% and 61.0%, respectively. In patients with high LSM, the use of FM VCTE improved the PPV from 71.4% to 84.4% for F2‐4 and from 61.0% to 88.9% for F3‐4. Liver biopsy could be spared in around 50–65% of patients. Conclusions Liver stiffness measurement alone can confidently exclude significant and advanced fibrosis in NAFLD patients. Using FM VCTE in patients with high liver stiffness can increase the positive predictive value to rule in F2‐4 and F3‐4.