Premium
Fluoro‐2‐deoxy‐ d ‐glucose positron emission tomography/computed tomography for the detection of proximal synchronous lesions in patients with obstructive colorectal cancer
Author(s) -
Kim Wan Soo,
Lee Hyo Sang,
Lee JeongMi,
Kwak Min Seob,
Hwang Sung Wook,
Park Sang Hyoung,
Yang DongHoon,
Kim KyungJo,
Myung SeungJae,
Yang SukKyun,
Byeon JeongSik
Publication year - 2017
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13486
Subject(s) - medicine , colonoscopy , colorectal cancer , positron emission tomography , standardized uptake value , radiology , lesion , tomography , pet ct , nuclear medicine , adenoma , cancer , pathology
Background and Aim We aimed to investigate the ability of fluoro‐2‐deoxy‐ d ‐glucose (FDG) positron emission tomography (PET)/computed tomography (CT) to detect synchronous neoplasms, specifically obstructive colorectal cancer (CRC) and CRC in the proximal colon and to suggest a management strategy based on FDG PET/CT findings. Methods From the CRC surgery database of our institution, 518 patients with obstructive CRC whose proximal colon could not be examined by colonoscopy and who underwent preoperative FDG PET/CT were eligible for this study. Of these, final analyses were performed in 345 patients who had reference standards for the proximal colon, which were a surgical colectomy specimen and/or postsurgical colonoscopy. The per‐patient and per‐lesion performances of FDG PET/CT for synchronous CRC diagnosis were determined. Results Of 345 patients, 14 (4.1%) had 14 proximal synchronous CRCs. Thirty‐four patients showed 39 areas of abnormal FDG uptake on PET/CT in the colon proximal to the obstructive CRC. PET/CT detected all of the 14 proximal synchronous CRCs. The per‐patient PET/CT sensitivity, specificity, positive predictive value, and negative predictive value for proximal synchronous CRC were 100%, 93.9%, 41.2%, and 100%, respectively. Per‐lesion values were 100%, 92.6%, 35.9%, and 100%, respectively. The per‐lesion sensitivity and negative predictive value of PET/CT for advanced adenoma were 45.5% and 92.7%, respectively. Conclusions The FDG PET/CT shows a high sensitivity and negative predictive value for the detection of proximal synchronous CRC in patients with obstructive CRC, enabling negative findings in the proximal colon on PET/CT to definitively exclude proximal synchronous CRC. Preoperative PET/CT recommended to determine the proper surgical plan in patients with obstructive CRC.