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Alterations of gut microbiota in patients with irritable bowel syndrome: A systematic review and meta‐analysis
Author(s) -
Zhuang Xiaojun,
Xiong Lishou,
Li Li,
Li Manying,
Chen Minhu
Publication year - 2017
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13471
Subject(s) - irritable bowel syndrome , gut flora , bacteroides , medicine , gastroenterology , lactobacillus , bifidobacterium , enterobacter , pathogenesis , etiology , meta analysis , dysbiosis , immunology , biology , bacteria , escherichia coli , biochemistry , gene , genetics
Background and Aims Alterations of gut microbiota were assumed to be the etiology and pathogenesis of irritable bowel syndrome (IBS) in some studies. However, alterations of gut microbiota in IBS patients had not been systematically assessed with a meta‐analysis. We performed a mate‐analysis to explore and compare the alterations of gut microbiota in IBS patients from China and other regions around the world. Methods Case–control studies detecting gut microbiota in IBS patients were identified through English and Chinese databases. The standardized mean difference (SMD) with 95% confidence interval (CI) of bacterial counts was calculated. Results Ten studies from China and seven studies from other regions around the world were included in our study. As compared with healthy controls, the SMDs of Bifidobacteria , Lactobacillus , Escherichia Coli , and Enterobacter in Chinese IBS patients were −1.42 (CI: −2.10, −0.75), −0.91 (95% CI: −1.31, −0.52), 0.83 (95% CI: 0.26, 1.40), and 0.57 (95% CI: 0.33, 0.82), respectively. But the SMDs of Bacteroides and Enterococcus were found no significant differences in Chinese IBS patients. However, the SMDs of Bifidobacteria and Bacteroides in IBS patients from other regions were −0.76 (CI: −1.43, −0.09) and 1.17 (CI: 0.00, 2.35), while the SMDs of Lactobacillus , E . Coli , Enterobacter , and Enterococcus were found no significant differences. Conclusions There were alterations of gut microbiota in IBS patients, and it implied that alterations of gut microbiota might be involved in the pathogenesis of IBS. However, the species‐specific alterations of gut microbiota were different between IBS patients from China and other regions.