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Sleep disturbance and enhanced esophageal capsaicin sensitivity in patients with gastroesophageal reflux disease
Author(s) -
Yi ChihHsun,
Lei WeiYi,
Hung JuiSheng,
Liu TsoTsai,
Orr William C,
Chen ChienLin
Publication year - 2016
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13428
Subject(s) - heartburn , gerd , medicine , sleep disorder , sleep (system call) , capsaicin , actigraphy , anesthesia , reflux , gastroenterology , circadian rhythm , disease , insomnia , pharmacology , receptor , computer science , operating system
Background and Aim Esophageal infusion of capsaicin‐containing red pepper sauce induced heartburn symptoms in patients with gastroesophageal reflux disease (GERD). We aimed to test the hypothesis whether sleep disturbance modulates esophageal sensitivity to capsaicin infusion in patients with GERD. Methods We enrolled 40 patients with their sleep quality measured by the Pittsburg Sleep Quality Index with > 5 indicating sleep disturbance. Esophageal sensation to capsaicin infusion was documented via measures of lag time to initial heartburn perception, heartburn intensity rating, and sensitivity score by esophageal infusion of capsaicin‐containing red pepper sauce. Objective sleep measures were assessed by ambulatory actigraphy. Results We found 22 patients with sleep disturbance. The patients with sleep disturbance had shorter lag time to initial heartburn perception ( P = 0.03) and greater sensory intensity rating ( P = 0.02). The sensitivity score for capsaicin infusion was greater in patients with sleep disturbance when compared with those without sleep disturbance ( P = 0.04). Actigraphy measures revealed that patients with sleep disturbance also had poor sleep efficiency ( P = 0.04), longer average awakening time ( P = 0.03), and greater total activity account ( P = 0.04). The lag time for perceiving capsaicin infusion was positively correlated with total sleep time ( r = 0.43, P = 0.03). Conclusions We have shown that GERD patients with sleep disturbance have significantly enhanced heartburn perception to capsaicin infusion as compared with those with normal sleep. Our findings suggest that sleep disturbance is associated with esophageal hypersensitivity to capsaicin infusion in patients with GERD.