Premium
Statin use and the risk of colorectal adenoma: A meta‐analysis
Author(s) -
Jung Yoon Suk,
Park Chan Hyuk,
Eun Chang Soo,
Park Dong Il,
Han Dong Soo
Publication year - 2016
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13393
Subject(s) - medicine , colorectal adenoma , odds ratio , adenoma , statin , confidence interval , relative risk , colorectal cancer , gastroenterology , meta analysis , colonoscopy , oncology , cancer
Background Although statin use has been reported to reduce the risk of colorectal cancer beyond its cholesterol‐lowering effects, the benefit of statins against colorectal adenoma has not been fully clarified. We aimed to investigate the association between statin use and the risk of colorectal adenoma. Methods We conducted a systematic literature search on MEDLINE, EMBASE, and the Cochrane Library using the primary keywords “adenoma,” “polyp,” “colorectal,” “colon,” “rectal,” “rectum,” “neoplasia,” “neoplasm,” “statin,” “3‐hydroxy‐3‐methylglutaryl‐coenzyme A,” and “HMG‐CoA.” Studies were included if they evaluated the association between statin use and adenoma and reported relative risks (RRs) or odds ratios or provided data for estimation. Pooled estimates were calculated using the random‐effects model. Results Six studies including 13 239 patients were analyzed. The median proportion of patients with any adenoma was 29.7% (range, 20.9–38.4%) in patients taking statins and 31.2% (range, 19.6–63.4%) in patients not taking statins across included studies. The median proportion of patients with advanced adenoma in those taking statins was 7.7% (range, 3.1–27.2%), whereas that in patients not taking statins was 11.3% (range, 3.5–32.4%). On meta‐analysis, statin use did not significantly affect the risk of any adenoma (pooled RR = 0.901; 95% confidence interval [CI], 0.735–1.104); however, it was associated with a lower risk of advanced adenoma (pooled RR = 0.833; 95% CI, 0.750–0.925). Conclusions Statin use seems to be associated with a reduced risk of advanced adenoma, but not any adenoma. Statins may prevent neoplastic progression of adenomas rather than the development of adenomas.