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Short sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta‐analysis
Author(s) -
Wijarnpreecha Karn,
Thongprayoon Charat,
Panjawatanan Panadeekarn,
Ungprasert Patompong
Publication year - 2016
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13391
Subject(s) - medicine , nonalcoholic fatty liver disease , meta analysis , confidence interval , hazard ratio , relative risk , risk factor , fatty liver , disease
Background and Aim Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Several studies have suggested that short sleep duration could be a risk factor for NAFLD. However, results of those reports are inconsistent. This meta‐analysis was conducted with an attempt to summarize all available data. Methods A comprehensive literature review was performed using MEDLINE and EMBASE database. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk of NAFLD among participants who had short sleep duration versus those with longer sleep duration were included. Pooled risk ratios and 95% confidence interval were calculated using a random‐effect, generic inverse variance method. Results Six studies met the eligibility criteria and were included in the meta‐analysis. The risk of NAFLD in participants who had short sleep duration was significantly higher than participants with longer sleep duration with pooled risk ratios of 1.19 (95% confidence interval, 1.04–1.36, I 2 = 0%). Conclusions Our study demonstrated a small but significantly increased risk of NAFLD among participants who had short sleep duration.