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Outcomes of intrahepatic cholangiocarcinoma with portal vein tumor thrombus following hepatic resection
Author(s) -
Lu Chong De,
Wang Kang,
Zhang Cun Zhen,
Zhou Fei Guo,
Guo Wei Xing,
Wu Meng Chao,
Cheng Shu Qun
Publication year - 2016
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13309
Subject(s) - medicine , intrahepatic cholangiocarcinoma , hazard ratio , portal vein , confidence interval , incidence (geometry) , thrombus , resection , retrospective cohort study , radiology , gastroenterology , surgery , physics , optics
Background and Aim Portal vein tumor thrombus (PVTT) is not commonly used in the treatment of intrahepatic cholangiocarcinoma (ICC), and its impact on the prognosis of ICC is unclear. We aimed to assess the outcomes of ICC with or without PVTT after hepatic resection. Methods From January 2000 to December 2005, the data from all consecutive patients with ICC who underwent hepatic resection at our hospital were retrospectively analyzed. According to the Cheng's PVTT Classification (types I–IV), we compared the survival outcomes of ICC patients (with or without PVTT) and prognosis of patients with ICC with different types of PVTT. Results Three hundred and three patients with ICC were enrolled in this study (59 with PVTT). The incidence of PVTT was 19.4% (59/303). The median survival times were 12.68 and 28.91 months for ICC patients with and without PVTT, respectively ( P < 0.001). The multivariate analysis demonstrated that PVTT (hazard ratio [HR] 1.783; confidence interval 95% [1.279; 2.487]) was an independent risk factor for overall survival. Patients with type I PVTT exhibited significantly better survival than those with types II and III PVTT. Conclusion The ICC patients with PVTT exhibit a poorer prognosis compared with ICC patients without PVTT after hepatic resection.