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Follicle‐stimulating hormone is associated with non‐alcoholic fatty liver disease in Chinese women over 55 years old
Author(s) -
Wang Ningjian,
Li Qin,
Han Bing,
Chen Yi,
Zhu Chunfang,
Chen Yingchao,
Xia Fangzhen,
Lu Meng,
Meng Ying,
Guo Yuyu,
Ye Lin,
Sui Chunhua,
Kuang Lin,
Lin Dongping,
Lu Yingli
Publication year - 2016
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13271
Subject(s) - medicine , insulin resistance , steatosis , fatty liver , endocrinology , follicle stimulating hormone , waist , hormone , obesity , luteinizing hormone , disease
Background and Aim Obesity and diabetes are related to non‐alcoholic fatty liver disease (NAFLD). A reduction in follicle‐stimulating hormone (FSH) is associated with obesity and diabetes in postmenopausal women. Thus, we aim to investigate whether FSH is associated with NAFLD in women over 55 who were postmenopausal with a high probability. Methods Our data were obtained from the 2014 Survey on Prevalence in East China for Metabolic Diseases and Risk Factors. A total of 1635 women at the age of 55–89 years were selected. The degrees of fatty liver were categorized into mild and moderate‐severe hepatic steatosis groups by ultrasonography. FSH and other sex hormones were measured by chemiluminescence. Results A total of 366 (22.4%) and 417 (25.5%) women had mild and moderate‐severe hepatic steatosis, respectively. FSH was negatively correlated with waist circumference, homeostasis model assessment of insulin resistance (HOMA‐IR), and other metabolic factors (all P < 0.05). After adjusting for age, estradiol, and total testosterone, increased quartiles of FSH were associated with significantly decreased odds ratios of mild and moderate‐severe groups (both P for trends <0.05). After further adjustment for waist circumference and HOMA‐IR, FSH was no longer associated with mild hepatic steatosis. The association of FSH with moderate‐severe hepatic steatosis was attenuated by waist circumference and HOMA‐IR but persisted in the fully adjusted model ( P for trend <0.01). Conclusion Follicle‐stimulating hormone was negatively associated with NAFLD in women over 55 years old. Adiposity and insulin resistance explained most of the association of mild hepatic steatosis and partially explained the association of moderate‐severe hepatic steatosis with FSH.