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Prevalence of celiac disease in Asia: A systematic review and meta‐analysis
Author(s) -
Singh Prashant,
Arora Shubhangi,
Singh Alka,
Strand Tor A,
Makharia Govind K
Publication year - 2016
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13270
Subject(s) - medicine , meta analysis , population , disease , prevalence , hepatology , epidemiology , demography , environmental health , sociology
Background and Aim Celiac disease (CD) is emerging in Asia. While a few population‐based studies from Asia have reported a prevalence of CD from 0.1% to 1.3%, the exact prevalence of CD in Asia is not known. We conducted a systematic review and meta‐analysis to estimate the prevalence of CD in Asia. Methods On search of literature, we found 1213 articles, of which 18 articles were included. Diagnosis of CD was based on European Society of Pediatric Gastroenterology, Hepatology and Nutrition guidelines. Results Pooled sero‐prevalence of CD in Asia was 1.6% in 47 873 individuals based on positive anti‐tissue transglutaminase and/or anti‐endomysial antibodies. Pooled prevalence of biopsy proven CD in Asia was 0.5% in 43 955 individuals. The prevalence of CD among women was higher than in men (0.5% vs 0.4%, P = 0.04). The pooled prevalence of CD was 0.3% in Iran, 0.5% in Turkey, 0.6% in India, and 0.7% in Israel. The pooled prevalence of CD was significantly higher in Israel and India as compared with that in Iran. Conclusions Celiac disease is not uncommon in Asia, and the sero‐prevalence and prevalence of CD in Asia are 1.6% and 0.5%, respectively. The prevalence of CD varies with gender and geographic location. There is a need for population‐based prevalence studies in many Asian countries to properly estimate the burden of CD in Asia.