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The value of 18 F‐fluorodeoxyglucose positron emission tomography for prediction of treatment response in gastrointestinal stromal tumors: a systematic review and meta‐analysis
Author(s) -
HassanzadehRad Arman,
Yousefifard Mahmoud,
Katal Sanaz,
Asady Hadi,
FardEsfahani Armaghan,
Moghadas Jafari Ali,
Hosseini Mostafa
Publication year - 2016
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13247
Subject(s) - medicine , meta analysis , gist , positron emission tomography , odds ratio , standardized uptake value , diagnostic odds ratio , nuclear medicine , stromal cell
Background Early detection of response to treatment is critically important in gastrointestinal stromal tumors (GIST). Therefore, the present systematic review and meta‐analysis assessed the value of 18 f‐fluorodeoxyglucose positron emission tomography ( 18 FDG–PET) on prediction of therapeutic response of GIST patients to systemic treatments. Methods The literature search was conducted using PubMed, SCOPUS, Cochrane, and Google Scholar databases, and review article references. Eligible articles were defined as studies included confirmed GIST patients who underwent 18 FDG–PET as well as assessing the screening role of it. Results Finally, 21 relevant articles were included. The analysis showed the pooled sensitivity and specificity of 18FDG–PET in evaluation of response to treatment of GIST patient were 0.90 (95% CI: 0.85–0.94; I 2 = 52.59, P = 0.001) and 0.62 (95% CI: 0.49–0.75; I 2 = 69.7, P = 0.001), respectively. In addition, the pooled prognostic odds ratio of 18 FDG–PET for was 14.99 (95% CI, 6.42–34.99; I 2 = 100.0, P < 0.001). The Meta regression showed that sensitivity of 18 FDG‐PET was higher if the sample size of study was equal or more than 30 cases (sensitivity = 0.93; 95% CI: 0.89–0.97), when using PET/CT (sensitivity = 0.92; 95% CI: 0.89–0.97), and self‐design criteria (sensitivity = 0.93; 95% CI: 0.87–1.0). Conclusion The present meta‐analysis showed 18 FDG–PET has a significant value in predicting treatment response in GIST patients.