Premium
Inflammatory bowel disease on the risk of acute pancreatitis: A population‐based cohort study
Author(s) -
Chen YuTso,
Su JiannSheng,
Tseng ChihWei,
Chen ChiaChang,
Lin ChengLi,
Kao ChiaHung
Publication year - 2016
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13171
Subject(s) - medicine , hazard ratio , cohort , acute pancreatitis , pancreatitis , inflammatory bowel disease , cohort study , proportional hazards model , hypertriglyceridemia , population , gastroenterology , confidence interval , disease , triglyceride , environmental health , cholesterol
Background and Aims: To determine whether inflammatory bowel disease (IBD) influences the risk of acute pancreatitis. Methods: We identified 11 909 patients diagnosed with IBD between 2000 and 2010 from Taiwan National Health Insurance Research Database as the study cohort. A comparison cohort comprised 47 636 age‐matched patients without IBD. Both cohorts were followed‐up until the end of 2010 or until being censored. Cox proportional hazards regression models were used to study the effects of IBD on the risks of acute pancreatitis. Results: The overall incidence of acute pancreatitis was 3.56‐fold higher in the study cohort than in the comparison cohort (31.8 vs 8.91 per 10 000 person‐years, crude hazard ratio [HR] = 3.56, 95% confidence interval [CI] = 2.96–4.28). After adjustment for age, sex, and comorbidities, namely alcohol‐related disease, biliary stone, hypertension, hyperlipidemia, diabetes mellitus, obesity, hepatitis B, hepatitis C, hypertriglyceridemia, cardiovascular diseases, chronic kidney disease, chronic obstructive pulmonary disease, and hypercalcemia, the adjusted HR for acute pancreatitis was 2.93‐fold higher (95% CI = 2.40–3.58) in the study cohort than in the comparison cohort. Conclusions: IBD is a risk factor for acute pancreatitis. © 2015 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd