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Reduced gland mucin‐specific O ‐glycan in gastric atrophy: A possible risk factor for differentiated‐type adenocarcinoma of the stomach
Author(s) -
Yamada Shigenori,
Okamura Takuma,
Kobayashi Satoshi,
Tanaka Eiji,
Nakayama Jun
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.13000
Subject(s) - atrophic gastritis , medicine , adenocarcinoma , cancer , gastric mucosa , gastroenterology , chronic gastritis , atrophy , mucin , gastritis , stomach , immunohistochemistry , pathology , gastric glands
Abstract Background and Aims O ‐glycans exhibiting terminal α1,4‐linked N ‐acetylglucosamine (α G lc NA c) are attached to MUC6 in gastric gland mucins and serve as a tumor suppressor for gastric adenocarcinoma. Gastric atrophy is associated with risk for gastric cancer. However, the significance of α G lc NA c expression in pyloric glands of chronic atrophic gastritis remains unknown. Here, we asked whether reduced α G lc NA c expression in chronic atrophic gastritis is associated with risk for gastric cancer. Methods We quantitatively analyzed expression of α G lc NA c relative to MUC6 in pyloric glands by immunohistochemistry in 67 patients with normal mucosa, 70 with chronic atrophic gastritis, 68 with intramucosal differentiated‐type adenocarcinoma, and 11 with intramucosal undifferentiated‐type adenocarcinoma. We also compared the Ki‐67 labeling index in gastric epithelial cells between chronic atrophic gastritis and normal gastric mucosa with respect to α G lc NA c reduction. Results In normal pyloric mucosa, α G lc NA c was co‐expressed with MUC6 . By contrast, in chronic atrophic gastritis, pyloric gland α G lc NA c expression was significantly reduced relative to MUC6 . In intramucosal gastric cancer, α G lc NA c expression in pyloric glands found just beneath differentiated‐type adenocarcinoma was also reduced relative to MUC6 . However, pyloric glands present beneath undifferentiated‐type adenocarcinoma exhibited no α G lc NA c decrease. The Ki‐67 labeling index in chronic atrophic gastritis showing α G lc NA c reduction was significantly increased relative to that in normal gastric mucosa. Conclusions Because α G lc NA c prevents the gastric cancer development, reduced α G lc NA c expression in chronic atrophic gastritis is a possible risk factor for differentiated‐type adenocarcinoma of the stomach.