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Thyroid function is associated with non‐alcoholic fatty liver disease in chronic hepatitis B ‐infected subjects
Author(s) -
Ding WenJin,
Wang ManMan,
Wang GongSui,
Shen Fen,
Qin JianJun,
Fan JianGao
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12998
Subject(s) - medicine , fatty liver , thyroid function , gastroenterology , thyroid disease , alcoholic hepatitis , alcoholic liver disease , liver function , disease , thyroid , cirrhosis
Background and Aims Associations between thyroid function and non‐alcoholic fatty liver disease ( NAFLD ) are unknown in chronic hepatitis B ( CHB )‐infected patients. Thus, the aim of the study was to investigate the prevalence of thyroid dysfunction and its relationship with NAFLD in CHB . Methods Consecutive naive CHB infected patients that had undergone liver biopsy and serum thyroid function tests between J anuary 2007 and D ecember 2011 were retrospective analyzed. NAFLD was diagnosed as at least 5% biopsy‐proven hepatic steatosis without significant alcohol consumption. Results A total of 1154 non‐alcoholics with CHB were included, 270 (23.39%) patients were found to have NAFLD , most of them (88.5%) with mild steatosis. The prevalence of hyperthyroidism and hypothyroidism (including subclinical and overt) was 1.56% and 1.64%, respectively, both with similar rates in patients with and without NAFLD (1.85% vs 1.47%, 1.48% vs 1.69%, respectively, both P > 0.05). The serum thyroid‐stimulating hormone ( TSH ) level in NAFLD patients was significantly higher than that in patients without NAFLD (2.22 ± 2.13 vs 1.61 ± 1.20 mIU/L, P < 0.05). After adjustment for age and gender, the elevated TSH level was associated with increased odds of having steatosis (odds ratio1.54, 95% confidence interval 1.049–2.271) instead of viral factors and hepatic inflammation and fibrosis. Conclusions Thyroid dysfunction is not common in CHB ‐infected patients, and the prevalence of hypothyroidism in CHB individuals with or without NAFLD is similar. However, increased serum TSH concentration at the normal range is a significant predictor of hepatic steatosis in patients with CHB .