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Prognostic value of long noncoding RNA HOTAIR in digestive system malignancies
Author(s) -
Wang Shuai,
Wang Zhou
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12940
Subject(s) - hotair , medicine , long non coding rna , hazard ratio , hox gene , confidence interval , oncology , meta analysis , multivariate analysis , proportional hazards model , rna , biology , gene expression , gene , genetics
Abstract Background and Aim HOX transcript antisense intergenic RNA ( HOTAIR ), a well‐known long noncoding RNA , has been found to play significant roles in several tumors. However, the clinical application value of HOTAIR in digestive system malignancies remains to be clarified. We aimed to explore comprehensively the potential role of HOTAIR as a prognostic indicator in digestive system malignancies. Methods Systematic search was performed in P ubmed, E mbase, C ochrane L ibrary, and W eb of S cience until J uly 5, 2014. A quantitative meta‐analysis was conducted with standard statistical methods for eligible papers on the prognostic value of HOTAIR in digestive system cancers. Results A total of 1059 patients from 13 studies were included in the meta‐analysis. A significant association was found between HOTAIR abundance and poor overall survival ( OS ) of patients with digestive system malignancies, with pooled hazard ratio ( HR ) of 2.587 (95% confidence interval [ CI ]: 2.054–3.259, P < 0.001). By combining HRs from Cox multivariate analyses, we found HOTAIR was an independent prognostic factor for OS without obvious heterogeneity ( HR : 2.405, 95% CI : 1.883–3.0722, P < 0.001). Subgroup analysis showed that tumor type, histology type, region, publication year, sample size, and quality score did not alter the predictive value of HOTAIR as an independent factor for survival. Meta‐regression and sensitivity analysis both suggested the reliability of our findings. A slight publication bias was observed. After adjustment by nonparametric “trim‐and‐fill” method, the corrected HRs had no significant change. Conclusion HOTAIR could be exploited as a novel prognostic biomarker for patients with digestive system malignancies.