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Usefulness of endoscopic ultrasound‐guided sampling using core biopsy needle as a percutaneous biopsy rescue for diagnosis of solid liver mass: Combined histological‐cytological analysis
Author(s) -
Lee Yun Nah,
Moon Jong Ho,
Kim Hee Kyung,
Choi Hyun Jong,
Choi Moon Han,
Kim Dong Choon,
Lee Tae Hee,
Lee Tae Hoon,
Cha SangWoo,
Kim Sang Gyune,
Kim Young Seok
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12922
Subject(s) - medicine , malignancy , endoscopic ultrasound , biopsy , radiology , fine needle aspiration , cytology , stain , cytopathology , sampling (signal processing) , percutaneous , pathology , staining , computer science , computer vision , filter (signal processing)
Background and Study Aims Endoscopic ultrasound ( EUS )‐guided fine needle aspiration ( EUS‐FNA ) is one of the alternative methods for tissue sampling of liver solid mass. However, the diagnostic efficacy using cytology alone was limited. In this study, we evaluate the diagnostic accuracy of EUS ‐guided fine needle biopsy ( EUS‐FNB ) as a percutaneous biopsy rescue for liver solid mass. Patients and Methods The EUS‐FNB using core biopsy needle for liver solid mass was performed prospectively for patients who were failure to acquire a tissue or achieve a diagnosis using percutaneous liver biopsy. The primary outcome was the diagnostic accuracy of EUS‐FNB for malignancy and specific tumor type. The secondary outcomes were the median numbers of passes required to establish a diagnosis, the proportions of patients in whom immunohistochemical ( IHC ) stain was possible and obtained adequate specimen, and safety of EUS‐FNB . Results Twenty‐one patients (12 women; mean age, 63 years [range, 37–81]) underwent EUS‐FNB for solid liver masses. The median number of needle passes was 2.0 (range, 1–5). On‐site cytology and cytology with P apanicolaou stain showed malignancy in 16 patients (76.2%) and 17 patients (81.0%), respectively. In histology with HE stain, 19 patients (90.5%) were diagnosed malignancy and optimal to IHC stain. The overall diagnostic accuracy for malignancy and specific tumor type were 90.5% and 85.7%, respectively. No complications were seen. Conclusions EUS‐FNB with core biopsy needle for solid liver mass may be helpful in the management of patients who are unable to diagnose using percutaneous liver biopsy.