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Interleukin‐8: A critical chemokine in biliary atresia
Author(s) -
Dong Rui,
Zheng Shan
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12900
Subject(s) - medicine , biliary atresia , inflammation , chemokine , fibrosis , immune system , immunology , mediator , pathology , liver transplantation , transplantation
Biliary atresia ( BA ) is characterized by periductular inflammation and fibrosis and is associated with the progressive obliteration of the bile ducts. The induction and maintenance of systemic and local inflammatory responses plays a pivotal role in this process. Interleukin‐8 ( IL ‐8) is an important mediator of inflammation and the immune response in human disease. IL ‐8 is overexpressed in BA , and its expression positively correlates with inflammation and liver fibrosis. In this review, we focus on the available evidence, recent insights, and future clinical and preclinical possibilities regarding the role of IL ‐8 in BA .