Premium
Demography and treatment response in patients with predominant non‐erosive reflux disease or functional dyspepsia
Author(s) -
Miwa Hiroto,
Haruma Ken,
Sakamoto Shigeru,
Sanada Katsuyuki,
Hiroi Shinzo,
Kinoshita Yoshikazu
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12877
Subject(s) - nerd , medicine , reflux , gastroenterology , lansoprazole , hiatal hernia , esophagogastroduodenoscopy , helicobacter pylori , body mass index , proton pump inhibitor , disease , gerd , endoscopy
Background and Aim Non‐erosive reflux disease ( NERD ) and functional dyspepsia ( FD ) share some common features, and the appropriateness of managing these diseases independently has been questioned. A post‐hoc subgroup analysis of the LEGEND study was performed to compare demographics and treatment response between patients with NERD and patients with FD . Methods Patients with reflux and dyspepsia symptoms who had no endoscopic evidence of mucosal breaks and/or erosions were included and divided into groups with predominant NERD ( n = 1546) or FD ( n = 614). Patients received lansoprazole for 4 weeks, and their symptoms were evaluated using questionnaires. Results FD patients were significantly younger than NERD patients (54 vs 60 years), more likely to have a body mass index < 25 kg/m 2 (72.4% vs 67.1%), less likely to have a hiatal hernia (24.0% vs 31.2%), and more likely to feel continuous stress (54.7% vs 48.0%). After 4 weeks of treatment, > 60% of both patients reported an improvement in reflux symptoms and in most dyspepsia symptoms. The improvement rate for reflux symptoms was lower in FD patients than in NERD patients ( P < 0.05), whereas the improvement rate for dyspepsia symptoms did not differ between patient groups. Conclusion Although no clinically significant differences in pathophysiology exist between NERD and FD , there are some between‐group differences in demographic characteristics and improvement rates for reflux symptoms after treatment with lansoprazole. It remains to be discussed whether it is necessary to make a strict differential diagnosis between these two conditions.