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Initial clinical trial of a novel hemostat, TDM ‐621, in the endoscopic treatments of the gastric tumors
Author(s) -
Yoshida Masashi,
Goto Naoki,
Kawaguchi Minoru,
Koyama Hidehiko,
Kuroda Junko,
Kitahora Tetsuji,
Iwasaki Hiroyuki,
Suzuki Shinji,
Kataoka Mikinori,
Takashi Fujii,
Kitajima Masaki
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12798
Subject(s) - medicine , hemostasis , hemostat , endoscopic submucosal dissection , endoscopic mucosal resection , surgery , adverse effect , endoscopy
Background and Aim The feasibility of TDM ‐621, the synthetic infectious agent‐free peptides, was tested in hemostasis of the bleeding after endoscopic treatments of the gastric tumors. Methods The patients who underwent endoscopic mucosal resection ( EMR ) or endoscopic submucosal dissection ( ESD ) were enrolled in the present study. The subject of hemostasis was the oozing after the EMR or ESD . The hemostatic effect, the secondary hemorrhage from one postoperative day to the day before discharge and operability were studied. Results The hemostatic effects were assessed in 12 patients. It was “remarkably effective” in 11 patients and “effective” in 1 patient. The operability was “very easy” in two patients, “easy” in eight patients and “acceptable” in two patients. No secondary hemorrhage was observed in all of 12 patients. No adverse effect considered to be related to TDM ‐621 was observed. Conclusion It was shown that hemostasis using TDM ‐621 was feasible after endoscopic treatments of the gastric tumors without any technical trouble or adverse event.