Premium
Assessment of liver fibrosis: The relationship between point shear wave elastography and quantitative histological analysis
Author(s) -
Ding Hong,
Ma Jiaojiao,
Wang Wenping,
Zeng Wenjiao,
Jiang Tao,
Huang Beijian,
Chen Shiyao
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12789
Subject(s) - medicine , elastography , pathological , scoring system , pathology , fibrosis , liver fibrosis , radiology , ultrasound
Background and Aim Traditional pathological scoring systems for liver fibrosis progression are predominantly based on the description of architectural changes with no consideration of the amount of collagen fiber deposition. Our purpose was to explore a true histological standard in accordance with the liver stiffness measured by point shear wave elastography ( PSWE ) in patients with chronic hepatitis B . Methods A total of 78 patients with liver neoplasms underwent liver stiffness measurements with PSWE as well as biochemical investigations within 3 days before partial hepatectomy. One tissue section of the liver specimens was stained with HE trichrome and evaluated traditionally with the S cheuer scoring system. The other tissue section was stained with picro S irius red and was evaluated according to the semiquantitative C hevallier et al . scoring system. In addition, this second tissue section was evaluated for the collagen proportionate area ( CPA ) with computer‐assisted digital image analysis. The reproducibility of PSWE technology was explored through the intra‐class correlation coefficient of a reliability analysis. Results The PSWE technology revealed good reproducibility in liver stiffness measurements, and the PSWE values increased with the pathological severity of liver fibrosis on both the S cheuer scoring system and the semiquantitative C hevallier et al . scoring system. PSWE values exhibited more reasonable relationships with CPA ( r = 0.628, P = 0.00 < 0.05) than with the S cheuer scoring system ( r = 0.473, P = 0.00 < 0.05) or the C hevallier et al . semiquantitative scoring system ( r = 0.487, P = 0.00 < 0.05). Conclusion CPA is a better pathological parameter than traditional semiquantitative scoring systems in accordance with liver stiffness measured by PSWE technology.