Effect of supplementation with rebamipide for H elicobacter pylori eradication therapy: A systematic review and meta‐analysis

Background and Aim Several studies have reported that the application of rebamipide during the eradication of H elicobacter pylori can improve the eradication rate. However, the efficacy and safety are controversial. The present study systematically evaluated whether rebamipide improves the eradication rate of H . pylori by conducting a meta‐analysis based on randomized controlled trials ( RCTs ). Methods Literature searches were conducted in the following database: P ub M ed, the C ochrane L ibrary, and the I gaku‐chuo‐zasshi database in J apan. A meta‐analysis of all RCTs comparing rebamipide supplementation with non‐rebamipide‐containing therapy was performed. Results We identified six randomized trials (611 patients). Pooled H . pylori eradication rates by per‐protocol analysis were 73.3% and 61.4% for patients with or without rebamipide, respectively. The odds ratio was 1.74 (95% confidence interval. 1.19–2.53). Conclusions Supplementation with rebamipide might be effective in increasing the H . pylori eradication rates of proton‐pump inhibitor–amoxicillin dual therapy.