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Pretreatment prediction of symptom response to proton pump inhibitor therapy
Author(s) -
Nagahara Akihito,
Miwa Hiroto,
Asaoka Daisuke,
Shimada Yuji,
Sasaki Hitoshi,
Matsumoto Kenshi,
Osada Taro,
Hojo Mariko,
Watanabe Sumio
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12744
Subject(s) - medicine , proton pump inhibitor
Abstract Background and Aim This prospective pilot study investigated whether it is possible to predict the therapeutic response in both the early phase (1 week) and sustained phase (4 weeks) before starting proton pump inhibitor ( PPI ) therapy for functional dyspepsia ( FD ) or non‐erosive reflux disease ( NERD ). Methods We administered rabeprazole 10 mg for 4 weeks to NERD / FD patients, who also answered a modified version of the F requency S cale for S ymptoms of gastroesophageal reflux disease ( GERD ) ( FSSG ), which added a pain score to the FSSG . Total score ( TS ), reflux score ( RS ), dysmotility score ( DS ), and pain score ( PS ) were analyzed. Symptom improvement was defined as ≥ 50% improvement in each score. Results We enrolled 83 patients (age [mean ± SD ] 50.8 ± 15.8 years, 29 males, 54 females), of whom 62 could be classified into four groups: achieved symptom improvement within 1 week and maintained it for 4 weeks ( E arly‐ R , 40.3%); achieved symptom improvement within 1 week but lost it after 4 weeks ( T emp‐ R , 9.7%); did not achieve symptom improvement within 1 week but did after 4 weeks ( L ate‐ R , 9.7%); and no improvement ( N on‐ R , 40.3%). Mean TS , RS , DS , and PS in the N on‐ R group were significantly higher than in the E arly‐ R group (23.9, 10.5, 11.0, and 2.4 vs 14.3, 6.8, 6.4, and 1.2). However, the T emp‐ R , L ate‐ R , and N on‐ R groups could not be distinguished by TS , RS , or DS . Conclusion The magnitude of the pretreatment modified FSSG score seemed to be associated with the response at 1 week and 4 weeks.