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Lymphangiogenesis in early and advanced gastric cancer: Is there any difference?
Author(s) -
RudnoRudzińska Julia,
Donizy Piotr,
Frejlich Ewelina,
Kotulski Krzysztof,
Dzięgiel Piotr,
Hałoń Agnieszka,
Kielan Wojciech
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12733
Subject(s) - lymphangiogenesis , lymphatic vessel , lymphatic system , medicine , stage (stratigraphy) , cancer , pathology , tumor stage , vascular endothelial growth factor c , vegf receptors , vascular endothelial growth factor , vascular endothelial growth factor a , biology , metastasis , paleontology
Abstract Background and Aim Gastric cancer ( GC ) in P oland is on the third place of men's mortality and on the fifth place of women's mortality in malignant neoplasms, and the percentage of diagnosed early GC is less than 20%. In this study, the relationship among lymphatic vessel density, marked with D 2‐40, expression of vascular endothelial growth factor ( VEGF )‐ C / D , VEGF receptor 3 VEGFR ‐3, and the stage of GC patient were investigated. Methods This study examined the relationships between the peritumoral lymphatic vessels ( PTL ) density and intratumoral lymphatic vessels ( ITL ) density stained immunohistochemically with D 2‐40/podoplanin, the expression of VEGF ‐ C / D and VEGFR ‐3, and the stage of 58 GC patients. Results Lymphatic vessel density measured by D 2‐40 decreases outside the tumor ( PTL ) and increases within the tumor ( ITL ) as the staging grows from I to III , whereas in the case of patients belonging to stage IV group, lymphatic vessel density decreases outside the tumor as well as within the tumor in comparison with the stage III group (not statistically significant). We observed a difference between morphology of the vessels within the tumor ( ITL s) and vessels that are located outside the tumor ( PTL s). PTL s were enlarged and unsqueezed as opposed to ITL s, which were collapsed. Conclusions (i) There is no significant correlation between the density of ITL nor PTL marked with D 2‐40 and the stage of GC . (ii) We did not observe relationship between expression of VEGF ‐ C / D and VEGFR ‐3 and the stage of GC . (iii) Further studies are needed to fully determine the role of PTL and ITL .