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Safety and efficacy of entecavir in adefovir‐experienced patients
Author(s) -
Nguyen Nghia H,
Trinh Huy N,
Nguyen Thuan T,
Do Son T,
Tran Phuong,
Nguyen Huy A,
Nguyen Khanh K,
Garcia Ruel T,
Lutchman Glen A,
Nguyen Mindie H
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12728
Subject(s) - adefovir , entecavir , medicine , lamivudine , gastroenterology , hepatitis b , multivariate analysis , hepatitis b virus , alanine aminotransferase , immunology , virus
Background and Aim Suboptimal viral suppression with adefovir ( ADV ) poses a challenge in managing chronic hepatitis B . Few studies have evaluated the efficacy of entecavir ( ETV ) in ADV ‐experienced patients. Our aim is to assess treatment effectiveness of ETV in ADV ‐experienced patients. Methods ADV ‐experienced patients switched to ETV were enrolled from six US clinics. Patients completed a median of 24 months of ETV after switch. Patients were categorized into partial responders (detectable HBV ‐ DNA at switch) or complete responders (undetectable HBV ‐ DNA at switch) to ADV . Primary and secondary outcome measurements were complete viral suppression ( CVS , HBV ‐ DNA < 60 IU/mL) and biochemical response ( BR , alanine aminotransferase [ ALT ] < 40 U/L), respectively. Results A total of 120 patients were included in the analysis (80 ADV partial responders; 40 ADV complete responders). In partial responders, CVS rate was 84% after 24 months of ETV . BR rate was 58% at switch to ETV and increased to 90% after 24 months. All complete responders continued to experience CVS after switch. On multivariate analysis inclusive of age, male gender, ALT level at switch, and history of lamivudine ( LAM ) exposure, we identified positive, hepatitis B e antigen status before ADV and higher HBV ‐ DNA level at time of switch as significant independent negative predictors of CVS . In eight patients with ADV resistance, seven achieved CVS after 24 months of ETV , and all achieved BR . Conclusion In ADV ‐experienced patients, high rates of CVS and BR can be achieved/sustained after switching to ETV , including those with ADV resistance or with prior exposure to LAM .