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Effect of T wist and B mi1 on intraductal papillary mucinous neoplasm of the pancreas
Author(s) -
Ishikawa Daichi,
Shimada Mitsuo,
Utsunomiya Tohru,
Morine Yuji,
Imura Satoru,
Ikemoto Tetsuya,
Arakawa Yusuke,
Kanamoto Mami,
Iwahashi Shuichi,
Saito Yu,
Yamada Shinichiro,
Miyake Hidenori
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12652
Subject(s) - intraductal papillary mucinous neoplasm , medicine , dysplasia , immunohistochemistry , pathology , carcinoma , pancreas , gastroenterology
Background Intraductal papillary mucinous neoplasm ( IPMN ) is a well‐established entity among pancreatic neoplasms that ranges from low‐grade dysplasia to invasive carcinoma. Epithelial‐mesenchymal transition ( EMT ) contributes to tumor progression in various cancers. Moreover, N otch signaling is one of the important upstream effectors of EMT promotion. Currently, it is unclear whether EMT causes pathological progression of IPMN . Aim We evaluated the expression of EMT ‐promoting transcription factors T wist and B cell‐specific M oloney murine leukemia virus insertion site 1 ( B mi1) in IPMN . Methods Patients who underwent resections at our institute and its affiliated hospital were enrolled in this study ( n = 35). Protein expression of EMT markers T wist, B mi1, J agged1, and E ‐cadherin in resected specimens was investigated by immunohistochemistry. Expression of these proteins was compared with the clinicopathological factors and patient survival. Results Positive expression of T wist and B mi1 was observed in 40.0% and 42.9% of IPMNs , respectively. T wist and B mi1 expression was significantly higher in IPMN s with high‐grade dysplasia ( P < 0.05) and invasive carcinoma ( P < 0.05) than that in IPMN s with low‐grade dysplasia. High expression of T wist was correlated with J agged1 expression and inversely correlated with expression of E ‐cadherin ( P = 0.06 and P < 0.05, respectively). In survival analyses, the recurrence rate was significantly higher in the group that showed simultaneous high expression of T wist and B mi1 ( P < 0.05). Conclusions Expression of T wist and B mi1 is associated with aggressiveness and poor prognoses of IPMN through EMT promotion that might be induced by N otch signaling.