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The role of F bxw7 expression in hepatocellular carcinoma and adjacent non‐tumor liver tissue
Author(s) -
Imura Satoru,
Tovuu LkhagvaOchir,
Utsunomiya Tohru,
Morine Yuji,
Ikemoto Tetsuya,
Arakawa Yusuke,
Kanamoto Mami,
Iwahashi Shuichi,
Saito Yu,
Takasu Chie,
Yamada Shinichiro,
Ishikawa Daichi,
Bando Yoshimi,
Shimada Mitsuo
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12623
Subject(s) - hepatocellular carcinoma , medicine , hepatectomy , immunohistochemistry , gene expression , pathology , messenger rna , clinical significance , tumor progression , tumor m2 pk , liver tumor , cancer research , gene , oncology , cancer , tumor marker , biology , resection , biochemistry , surgery
Abstract Background and Aim F bxw7 is a tumor suppressor gene through ubiquitination and degradation of multiple oncoproteins. Loss of F bxw7 expression is frequently observed in various human cancers. In the present study, we examined the role of F bxw7 expression in both non‐tumor liver tissues and tumor tissues on clinicopathological significance. Methods Sixty‐six patients with hepatocellular carcinoma ( HCC ), who underwent hepatectomy, were divided into two groups: high and low gene‐expression group, based on the F bxw7 expression level. We compared the clinicopathological factors between the high expression and low expression groups in both tumor and non‐tumor tissues. Results F bxw7 messenger RNA expression level in the non‐tumor tissues was significantly higher than that in the tumor tissues. In the analysis of F bxw7 expression in tumor and non‐tumor tissues, disease‐free survival rate in the F bxw7 high expression group was significantly higher than that in the low expression group. In multivariable analysis, F bxw7 low expression in both tumor and non‐tumor tissue was detected as the strongest independent risk factor for HCC recurrence. Conclusions Low F bxw7 expression in both tumor and non‐tumor tissue may be an independent prognostic factor for tumor recurrence after hepatectomy in patients with HCC .