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Oral antiviral therapy improves the diagnostic accuracy of alpha‐fetoprotein levels in patients with chronic hepatitis B
Author(s) -
Shim JaeJun,
Kim Jung Wook,
Lee Chang Kyun,
Jang Jae Young,
Kim ByungHo
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12612
Subject(s) - medicine , hepatocellular carcinoma , antiviral therapy , gastroenterology , biomarker , alpha fetoprotein , incidence (geometry) , chronic hepatitis , antiviral treatment , immunology , virus , biochemistry , chemistry , physics , optics
Background and Aims Analysis of alpha‐fetoprotein ( AFP ) levels affords limited diagnostic accuracy because of the high false‐positive rates, especially in those with active chronic hepatitis B ( CHB ). We measured AFP levels before and after commencement of oral antiviral therapy and explored the utility of these data in terms of early detection of hepatocellular carcinoma ( HCC ) in patients with CHB . Methods A total of 207 patients with CHB who were treated with an oral antiviral agent were consecutively included. Dynamic changes in AFP levels and the diagnostic utility of such changes for HCC detection during the therapy were explored. Results The proportions of patients showing elevated AFP levels (≥ 20 ng/mL) were 22.2%, 5.5%, and 1.3% at baseline; and at 6 and 12 months after commencement of antiviral therapy, respectively. All patients who did not suffer from HCC exhibited normalization of AFP levels at 12 months. The cumulative incidence of HCC was 9.5% during 36 months of follow‐up. If AFP levels were over 20 ng/mL after 12 months of antiviral treatment, the probability of HCC development approached certainty. The positive predictive value for HCC development remained at 100% in patients prescribed long‐term (≥ 12 months) antiviral therapy, if AFP levels persistently or abruptly elevated more than 12 ng/mL. Conclusions In the era of oral antiviral agents, AFP might be a useful biomarker for HCC surveillance in patients with CHB .