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Associations of FUT2 and FUT3 gene polymorphisms with C rohn's disease in C hinese patients
Author(s) -
Hu Dingyuan,
Shao Xiaoxiao,
Xu Changlong,
Xia Shenglong,
Yu Liqin,
Jiang Lijia,
Jin Jie,
Lin Xiuqing,
Jiang Yi
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12599
Subject(s) - genotype , allele , odds ratio , haplotype , confidence interval , medicine , immunology , gastroenterology , gene , microbiology and biotechnology , biology , genetics
Background and Aim FUT2 and FUT3 genes are responsible for the formation of histo‐blood group antigens, which act as binding sites for some intestinal microbes. Several studies suggested that FUT2 gene might affect the intestinal microbiota composition and modulate innate immune responses. However, the effect of FUT2 polymorphisms on C rohn's disease ( CD ) is uncertain. Our study aimed to analyze associations of CD with FUT2 and FUT3 polymorphisms in C hinese population. Methods A total of 273 CD patients and 479 controls were recruited. The genotypes of FUT2 (rs281377, rs1047781, and rs601338) and FUT3 (rs28362459, rs3745635, and rs3894326) were detected by SN a P shot analysis. Results Compared with controls, homozygote TT of FUT2 (rs1047781) was significantly increased in CD patients ( TT vs others; P = 0.002, odds ratio [ OR ] = 1.767, 95% confidence interval [ CI ] = 1.235–2.528). The haplotype TT formed with FUT2 (rs281377) and (rs1047781) was more prevalent in CD patients than in controls (48.9% vs 43.5%, P = 0.046). Mutant T allele and homozygote TT of FUT2 (rs1047781) were increased in colonic CD patients compared with controls ( P < 0.001, OR = 1.843, 95% CI = 1.353–2.512; P < 0.001, OR = 2.607, 95% CI = 1.622–4.191, respectively). Although allele and genotypic distributions of FUT3 were not statistically different between CD patients and controls, mutant allele and genotype of FUT3 (rs28362459) and (rs3745635) were significantly discrepant in three subgroups of CD patients according to lesion locations (all P < 0.05). Conclusions Our study strongly implicates the polymorphic locus of FUT2 (rs1047781) in CD susceptibility in C hinese population. Mutations of FUT3 (rs28362459) and (rs3745635) might influence the lesion locations in CD patients.