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The association of SLC 6 A 4 5‐ HTTLPR and TRPV 1 945 G > C with functional dyspepsia in K orea
Author(s) -
Hwang Sung Wook,
Kim Nayoung,
Jung HyeKyung,
Park Ji Hyun,
Choi Yoon Jin,
Kim Heebal,
Kim Jaemin,
Kim Joo Sung,
Jung Hyun Chae
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12596
Subject(s) - genotype , odds ratio , medicine , confidence interval , gastroenterology , postprandial , immunology , biology , genetics , gene , insulin
Background and Aim The association of various genetic polymorphisms with functional dyspepsia ( FD ) has been suggested, but the results were still controversial. The aim of the present study was to assess the association of GNB 3 825 C > T , SLC 6 A 4 5‐ HTTLPR , ADRA 2 A ‐ 1291 C > G , CCK ‐1 R intron 779 T > C , and TRPV 1 945 G > C polymorphisms with FD based on R ome III criteria in K orea. Methods Study subjects were prospectively recruited from visitors to S eoul N ational U niversity B undang H ospital between 2009 and 2012. One hundred and twelve FD patients and 269 controls were enrolled. Results In SLC 6 A 4 5‐ HTTLPR polymorphism, the frequency of S / S genotype was significantly lower than that of L / L + L / S genotype in FD compared to controls ( P < 0.05). After stratification according to Helicobacter pylori infection, the S / S genotype was significantly associated with H . pylori ‐positive epigastric pain syndrome ( EPS ) patients (adjusted odds ratio ( OR ) 0.46; 95% confidence interval ( CI ) 0.22–0.99; P = 0.048). In TRPV 1 945 G > C polymorphism, the frequency of C / C genotype was lower in FD compared to controls ( P = 0.057). The C carrier and C / C genotype was significantly associated with postprandial distress syndrome ( PDS ) and EPS , respectively (adjusted OR 0.47 and 0.43; 95% CI 0.25–0.90 and 0.20–0.93; P = 0.021 and 0.033). After stratification, the significant associations remained in H . pylori ‐positive PDS and EPS patients (adjusted OR 0.37 and 0.28; 95% CI 0.16–0.88 and 0.09–0.85; P = 0.024 and 0.025). Conclusions The genetic polymorphism of SLC 6 A 4 5‐ HTTLPR and TRPV 1 945G> C could be one of the pathophysiological factors of FD , especially in the case of H . pylori ‐positive patients in K orea.