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Stathmin overexpression identifies high risk for lymphatic metastatic recurrence in p N 0 esophageal squamous cell carcinoma patients
Author(s) -
Akhtar Javed,
Wang Zhou,
Jiang Wen Peng,
Bi Ming Ming,
Zhang Zhi Ping
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12498
Subject(s) - medicine , esophagectomy , lymphatic system , lymphovascular invasion , stathmin , immunohistochemistry , oncology , esophageal squamous cell carcinoma , lymph node , esophageal cancer , metastasis , carcinoma , pathology , gastroenterology , cancer , biochemistry , chemistry , phosphorylation
Background and Aim Common patterns of the operative failure after Ivor‐Lewis esophagectomy in esophageal squamous cell carcinoma ( ESCC ) patients are locoregional lymph node metastasis. It is clinically significant to investigate the biological markers to predict the subset of patients who are at higher risk of lymphatic metastatic recurrence. Our research aimed to investigate the association between the Stathmin ( STMN ‐1) gene expression and lymphatic metastatic recurrence in p N 0 ESCC patients after surgery. Methods One hundred seventy‐four patients who suffered from mid‐thoracic ESCC and completely resected with I vor‐ L ewis esophagectomy were enrolled in our study. The entire patients were restricted to p N 0 ESCC . Tissue specimens were examined for STMN ‐1 expression levels by immunohistochemistry and Western blotting methods. The correlation of STMN ‐1 levels with clinicopathological variables, prognosis, and metastatic potential was analyzed. Results One hundred patients had STMN ‐1 protein overexpression (57.47%), and the patients with overexpression were accompanied by significantly higher rate of lymphatic metastatic recurrence as compared with patients who had low STMN ‐1 expression ( P = 0.003). Multivariable Cox regression analysis revealed that the STMN ‐1 protein expression and T classification were independent factors to predict the lymphatic metastatic recurrence ( P = 0.007, P = 0.000, respectively). Conclusions Even p N 0 ESCC are a potential to lymphatic metastatic recurrence. Stathmin overexpression can be used as a marker to identify those patients who are at high risk for lymphatic metastatic recurrence in p N 0 ESCC after an I vor‐ L ewis esophagectomy.