Premium
Distribution of interferon lambda‐3 gene polymorphisms in A ustralian patients with previously untreated genotype 1 chronic hepatitis C : Analysis from the PREDICT and CHARIOT studies
Author(s) -
Roberts Stuart K,
Mitchell Joanne,
Leung Reynold,
Booth David,
Bollipo Steven,
Ostapowicz George,
Sloss Andrew,
McCaughan Geoffrey W,
Dore Gregory J,
Thompson Alexander,
Crawford Darrell HG,
Sievert William,
Weltman Martin,
Cheng Wendy,
George Jacob
Publication year - 2014
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12424
Subject(s) - genotype , medicine , genotyping , gastroenterology , single nucleotide polymorphism , hepatitis c , immunology , gene , biology , genetics
Background and Aims The aim of this study was to examine the distribution of interferon lambda‐3 ( IFN ‐λ3) gene polymorphisms in previously untreated A ustralian patients with genotype 1 ( Gt1 ) chronic hepatitis C ( CHC ) and to compare the IFN ‐λ3 genotype frequency among the different ethnic populations. Methods This was a prospective, multicenter, observational study undertaken by the A ustralian L iver A ssociation C linical R esearch N etwork. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN ‐λ3 single nucleotide polymorphisms were genotyped by the A pplied B iosystems's T aqman single nucleotide polymorphism genotyping assay. Results Between M ay 2012 and J une 2012, 1132 patients were recruited from 38 treatment clinics across A ustralia. Also, 561 subjects from the CHARIOT (collaborative group hepatitis C study using high dose Pegasys RBV Induction dose in genotype one) study of high‐dose interferon who had baseline serum available were retrospectively tested. The overall frequency of IFN ‐λ3 rs12979860 CC/CT/TT genotypes was 36%, 52%, and 12%, and that of rs8099917 TT/TG/GG genotypes was 54%, 41%, and 5%, respectively. The prevalence of the favorable IFN ‐λ3 rs12979860 CC and rs8099917 TT genotypes in C auscasians, A sians, A boriginals, M aori/ P acific I slanders, and M editerraneans was 32% and 52%, 80% and 86%, 33% and 63%, 77% and 88%, and 19% and 29%, respectively. Compared with C aucasians, the frequency of IFN ‐λ3 CC was significantly higher among A sians ( P < 0.0001) and M aori/ P acific I slander subjects ( P < 0.0001). Conclusions The distribution of IFN ‐λ3 polymorphisms among untreated patients with Gt1 CHC in A ustralia appears similar to that reported from N orth A merica. The frequency of the favorable response alleles varies considerably according to ethnicity, being more common in self‐reported A sians and M aori/ P acific I slanders than C aucasians, A boriginals, and M editerraneans.