Premium
Ethnicity is a strong predictor for H elicobacter pylori infection in young women in a multi‐ethnic E uropean city
Author(s) -
Hollander Wouter J,
Holster I Lisanne,
Hoed Caroline M,
Deurzen Frances,
Vuuren Anneke J,
Jaddoe Vincent W,
Hofman Albert,
Perez Perez Guillermo I,
Blaser Martin J,
Moll Henriëtte A,
Kuipers Ernst J
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12315
Subject(s) - medicine , caga , demography , confidence interval , odds ratio , socioeconomic status , ethnic group , helicobacter pylori , epidemiology , cohort , population , prospective cohort study , logistic regression , immunology , environmental health , biochemistry , chemistry , sociology , virulence , anthropology , gene
Background and Aim At the same time that H elicobacter pylori prevalence is declining in W estern countries, immigrants from developing countries with high H . pylori prevalence have settled in W estern urban areas. Actual epidemiological data on H . pylori in a migrant community may help in realizing a more selective approach to assess H . pylori ‐related diseases. We aimed to define H . pylori prevalence as well as risk groups for H . pylori in a cohort of young women living in a multi‐ethnic E uropean city. Methods We measured Immunoglobulin G (IgG) anti‐ H . pylori and CagA ‐antibodies in serum of pregnant women included in a population‐based prospective cohort study, the Generation R study. Information on demographics and socioeconomic status was collected by questionnaires. Chi‐square and logistic regression were used. Results In total, 3146 (46%) of the 6837 tested women (mean age 29.7 ± 5.3) were H . pylori‐ positive and 1110 (35%) of them were CagA ‐positive. The H . pylori prevalence in D utch women was 24%, which was significantly lower than in non‐ D utch women (64%; P < 0.001). In particular, H . pylori positivity was found in 92% of Moroccan (odds ratio 19.2; 95% confidence interval 11.8–32.0), 80% of C ape V erdean (7.6; 5.0–11.5), 81% of T urkish (9.0; 6.7–12.1), 60% of D utch A ntillean (3.3; 2.3–4.7), and 58% of S urinamese women (3.0; 2.3–3.8). Among H . pylori‐ positive D utch subjects, 19% were CagA ‐positive compared with 40% of the non‐ D utch subjects ( P < 0.001). Conclusions Despite a general trend of declining prevalence in W estern countries, H . pylori remains highly prevalent in migrant communities, which may constitute target groups for screening and eradication to prevent H . pylori ‐related diseases.