Premium
Chronic hepatitis C infection is associated with insulin resistance and lipid profiles
Author(s) -
Dai ChiaYen,
Yeh MingLun,
Huang ChungFeng,
Hou ChenHsiu,
Hsieh MingYen,
Huang JeeFu,
Lin ILing,
Lin ZuYau,
Chen ShinnChern,
Wang LiangYen,
Chuang WanLong,
Yu MingLung,
Tung HungDa
Publication year - 2015
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12313
Subject(s) - insulin resistance , medicine , diabetes mellitus , insulin , endocrinology , body mass index , cholesterol , alanine transaminase , hepatitis c virus , hepatitis c , lipid profile , gastroenterology , immunology , virus
Background and Aim Chronic hepatitis C virus ( HCV ) infection has been suggested to be associated with non‐insulin‐dependent diabetes mellitus and lipid profiles. This study aimed to investigate the possible relationships of insulin resistance ( IR ) and lipid profiles with chronic hepatitis C ( CHC ) patients in T aiwan. Methods We enrolled 160 hospital‐based CHC patients with liver biopsy and the 480 controlled individuals without CHC and chronic hepatitis B from communities without known history of non‐insulin‐dependent diabetes mellitus. Fasting plasma glucose, total cholesterol, high‐density lipoprotein cholesterol ( HDL ‐ C ), low‐density lipoprotein cholesterol ( LDL ‐ C ), triglycerides ( TGs ), alanine aminotransferase, and serum insulin levels, and homeostasis model assessment ( HOMA‐IR ) were tested. Results When comparing factors between CHC patients, and sex‐ and age‐matched controls who had no HCV infection, patients with HCV infection had a significantly higher alanine aminotransferase level, fasting plasma glucose level, insulin level, and HOMA‐IR ( P < 0.001, P = 0.023, P = 0.017, and P = 0.011, respectively), and significantly lower TG level ( P = 0.023), total cholesterol, and HDL ‐ C and LDL ‐ C levels (all P < 0.001) than 480 controls. In multivariate logistic regression analyses, a low total cholesterol, a low TGs , and a high HOMA‐IR are independent factors significantly associated with chronic HCV infection. In the 160 CHC patients (41 patients with high HOMA‐IR [> 2.5]), a high body mass index, TGs , and HCV RNA level are independent factors significantly associated with high HOMA‐IR in multivariate logistic analyses. Conclusions Chronic HCV infection was associated with metabolic characteristics including IR and lipid profile. IR was also associated with virological characteristics.