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Clinicopathologic features of hyperplastic/serrated polyposis syndrome in Japan
Author(s) -
Miwata Tomohiro,
Hiyama Toru,
Oka Shiro,
Tanaka Shinji,
Shimamoto Fumio,
Arihiro Koji,
Chayama Kazuaki
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12307
Subject(s) - medicine , hyperplastic polyp , colonoscopy , colorectal cancer , gastroenterology , population , endoscopy , cancer , environmental health
Background and Aim Hyperplastic/serrated polyposis syndrome ( HPS ) is a condition characterized by multiple hyperplastic/serrated colorectal polyps. The risk of colorectal cancer ( CRC ) is increased in HPS . The clinicopathologic characteristics of HPS in J apanese patients are unknown. The aim of this study is to clarify the clinicopathologic features of HPS in J apanese patients. Methods We retrieved records of patients diagnosed with HPS between A pril 2008 and M arch 2011 from the endoscopy database of H iroshima U niversity H ospital. In addition, we mailed a questionnaire to the hospital's 13 affiliated hospitals in J uly 2012. Data collected from the database and questionnaires included patient age, sex, number of hyperplastic/serrated polyps and tubular adenomas, size of the largest polyp, polyp location, resection for polyps, coexistence of HPS with CRC , and the diagnostic criterion met. Results Of the 73 608 patients who underwent colonoscopy, 10 (0.014%) met the criteria for HPS . The mean age of these patients was 58.3 years, and 6 (60%) were men. No subjects had a first‐degree relative with HPS . Four (40%) HPS patients had more than 30 hyperplastic/serrated polyps, and average size of the largest polyp was 19 mm. Three (30%) HPS patients had coexistence of HPS with CRC . In these 3 patients, polyps were observed throughout the colorectum. Conclusions Although HPS was a rare condition in the overall study population, patients with the disease may have high risk of CRC . HPS should be diagnosed correctly and followed up carefully.