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Normative data of high‐resolution impedance manometry in the C hinese population
Author(s) -
Shi Yinan,
Xiao Yinglian,
Peng Sui,
Lin Jinkun,
Xiong Lishou,
Chen Minhu
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12285
Subject(s) - medicine , interquartile range , peristalsis , supine position , esophageal motility disorder , population , high resolution manometry , gastroenterology , percentile , cardiology , achalasia , esophagus , statistics , mathematics , environmental health
Background and Aim Current normative data of high‐resolution manometry have been obtained from W estern populations, and esophageal motility disorders have been categorized using C hicago classification. However, the utility of high‐resolution impedance manometry ( HRiM ) in the C hinese population has not been evaluated. The study aimed to investigate the normal reference of esophageal motility in healthy volunteers (as defined by C hicago classification) using HRiM . Methods Healthy, fasted volunteers underwent HRiM in a supine position with 10 liquid swallows and 10 viscous swallows. Integrated relaxation pressure ( IRP ), distal contractile integral ( DCI ), contractile front velocity ( CFV ), and distal latency were calculated. The interquartile ranges and the 95th percentile range for each metric were obtained. Results Forty‐two healthy volunteers were enrolled with 411 total liquid swallows and 398 viscous swallows available for analysis. A 20.5 mmHg of IRP and a 3195 mmHg·s·cm of DCI as the 95th percentile for liquid swallows were established. Using the reference range defined by C hicago classification, 6.3% (26/411) weak peristalsis and 0.7% (3/411) failed peristalsis for liquid swallows were observed; 12 (28.6%, 12/42) and 2 (4.7%, 2/42) individuals were diagnosed as esophagogastric junction outflow obstruction and weak peristalsis for liquid swallows. Compared with liquid swallows, viscous swallows had a decreased IRP ( P  = 0.000) and CFV ( P  = 0.000), and an unchanged DCI ( P  = 0.211). Conclusions HRiM normative data of both liquid and viscous swallows from healthy C hinese volunteers were established. The IRP and CFV were significantly decreased in the viscous swallows compared with those of the liquid swallows.

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