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Delay of second‐line eradication therapy for H elicobacter pylori can increase eradication failure
Author(s) -
Nishizawa Toshihiro,
Suzuki Hidekazu,
Takahashi Masahiko,
Suzuki Masayuki,
Hibi Toshifumi
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12281
Subject(s) - medicine , regimen , second line , second line treatment , gastroenterology , surgery , first line , chemotherapy
Abstract Background and Aim The interval between first‐line H elicobacter pylori eradication treatment and second‐line treatment may be critical to the second‐line therapeutic effect. We attempted to assess the association between the second‐line eradication rates and the treatment interval. Methods Data of patients, who were administered the second‐line H . pylori eradication regimen at T okyo M edical C enter between 2008 and 2012, were reviewed. Results Of the 148 patients enrolled, one patient dropped out. The eradication rates were 88.6% (intention‐to‐treat [ ITT ]) and 89.3% (per‐protocol [ PP ]) for early eradication group (eradication interval < 180 days, patients number 132) and 68.8% ( ITT and PP ) for delayed eradication group (eradication interval ≥ 180 days, patients number 16). The eradication rate in the delayed eradication group was significantly lower than in the early eradication group ( P = 0.027 [ ITT ] and 0.021 [ PP ]). The eradication interval in the subjects showing eradication failure (124.0 ± 96.8 days, patients number 19) was significantly longer than those showing successful eradication (85.8 ± 56.9 days, patients number 128, P = 0.008). Conclusion Our results suggest that the delay of second‐line treatment should be avoided.