Premium
Applicability of second‐generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study
Author(s) -
Hosoe Naoki,
Matsuoka Katsuyoshi,
Naganuma Makoto,
Ida Yosuke,
Ishibashi Yuka,
Kimura Kayoko,
Yoneno Kazuaki,
Usui Shingo,
Kashiwagi Kazuhiro,
Hisamatsu Tadakazu,
Inoue Nagamu,
Kanai Takanori,
Imaeda Hiroyuki,
Ogata Haruhiko,
Hibi Toshifumi
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12203
Subject(s) - medicine , capsule endoscopy , colonoscopy , gastroenterology , ulcerative colitis , endoscope , inflammatory bowel disease , capsule , cathartic , surgery , disease , colorectal cancer , botany , cancer , biology
Abstract Background and Aim Colon capsule endoscopy has already been used for colon visualization and detection of polyps but its applicability to inflammatory bowel disease is still unconfirmed. The aim of this study was to assess the feasibility of evaluating the severity of mucosal inflammation in patients with ulcerative colitis ( UC ) using a second‐generation colon capsule endoscope ( CCE ‐2). Methods Forty patients with histological confirmed diagnosis of UC were enrolled. Low‐volume (2 L) polyethylene glycol solution with prokinetics (mosapride citrate and metoclopramide) regimen was used for the bowel preparation. In Phase 1, consisting of 10 patients, to confirm appropriate CCE ‐2 bowel preparation for UC . In Phase 2, consisting of 30 patients, CCE ‐2 was performed with a fixed bowel preparation regimen. CCE ‐2 findings were recorded for 8 h starting from capsule ingestion and conventional colonoscopy was subsequently performed on the same day. CCE ‐2 procedure completion rate and the colon cleansing level with a 4‐point grading scale (poor, fair, good, and excellent) were evaluated in Phase 2. Correlations between M atts endoscopic scores as judged by CCE ‐2 and conventional colonoscopy were calculated. Results CCE ‐2 procedure was completed within 8 h in 69% of the patients. The proportion of patients with good or excellent cleansing level was below 50%. However, M atts endoscopic scores determined by CCE ‐2 showed a strong correlation with scores obtained by conventional colonoscopy (average ρ = 0.797). Conclusions Although modifications in bowel preparation are needed, CCE ‐2 might be feasible for assessing the severity of mucosal inflammation in patients with UC .