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Proteomics and metabolomics in inflammatory bowel disease
Author(s) -
Yau Yunki,
Leong Rupert W,
Zeng Ming,
Wasinger Valerie C
Publication year - 2013
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.12193
Subject(s) - proteomics , inflammatory bowel disease , context (archaeology) , metabolomics , medicine , disease , ulcerative colitis , genomics , bioinformatics , computational biology , genome , biology , pathology , genetics , paleontology , gene
Genome‐wide studies in inflammatory bowel disease ( IBD ) have allowed us to understand C rohn's disease and ulcerative colitis as forms of related autoinflammatory disorders that arise from a multitude of pathogenic origins. Proteomics and metabolomics are the offspring of genomics that possess unprecedented possibilities to characterize unknown pathogenic pathways. It has been about a decade since proteomics was first applied to IBD , and 5 years for metabolomics. These techniques have yielded novel and potentially important findings, but turning these results into beneficial patient outcomes remains challenging. This review recounts the history and context of clinical IBD developments before and after proteomics and metabolomics IBD in this field, discusses the challenges in consolidating high complexity data with physiological understanding, and provides an outlook on the emerging principles that will help interface the bioanalytical laboratory with IBD prognosis.